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In patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid.

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Musculoskeletalmyopathyelevated CPKmyotoniamuscle weaknessmuscle painrhabdomyolysis.

Carcinogenicity studies of colchicine have not been conductedDue to the potential for colchicine to produce aneuploid cellscells with an unequal number of chromosomescolchicine presents a theoretical increased risk of malignancy.

Administration with food has no effect on the rate or extent of colchicine absorptionColchicine is not effectively removed by hemodialysis.

Case reports and epidemiology studies in human male subjects on colchicine therapy indicate that infertility from colchicine is rareA case report indicated that azoospermia was reversed when therapy was stoppedCase reports and epidemiology studies in female subjects on colchicine therapy have not established a clear relationship between colchicine use and female infertility.

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